Evaluation of TP53 and HER-2/neu Genes Expression Levels in Gestational Trophoblastic Diseases Cases and Determining Their Predictive Value in Diagnosis of Malignancy and Disease Progression

Background: Gestational trophoblastic disease (GTD) is a general term that includes several types of pathologically different diseases, which range from hydatidiform mole to choriocarcinoma. Early differentiation these important determine treatment strategy and prognosis. Objectives: Genetic markers such as TP53 HER-2/neu expression are recently shown have diagnostic prognostic values. The aim this study was evaluate its significance. Methods: We enrolled 62 patients diagnosed with GTD referred Imam Hossein Hospital in Tehran, Iran between 2012 2017. Endometrial pathologic specimens were stained, using the immunohistochemistry (IHC) method for genes. Expression levels determined by IHC compared final diagnoses, one-way ANOVA test (analysis variances), detects significant differences means 3 or more independent groups. Results: Out participants, 32 24 cases partial complete mole, respectively. Four had invasive only 2 Analysis demonstrated both genes significantly higher among form choriocarcinoma non-invasive (P < 0.05 genes). receiver operating characteristic (ROC) curve each gene showed than 55% positive staining can differentiate 100% sensitivity, 92.9% specificity. Conclusions: might serve potential aid benign malignant GTDs future target adjusting based on levels.